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Job description Site Name: USA - Pennsylvania - Upper Providence, GSK HQ, UK - Hertfordshire - Stevenage, USA - Massachusetts - Waltham Posted Date: Jan GSK is seeking a highly skilled Senior Medical Director, Clinical Development, for an Advanced Pipeline Unit (APU) Hepatology group to provide clinical and scientific leadership for potential new, established and emerging indications for assets in clinical development with a strong focus on steatotic liver disease (SLD), including alcohol-associated liver disease (ALD). You will work with project teams to plan and ensure delivery of clinical research and development activities and establish efficient collaboration throughout all stages of development. You will report to the Senior Director/Clinical Development Lead for an asset in the SLD therapeutic area. This role is pivotal in driving GSK's mission to deliver transformative medicines to patients, ensuring clinical excellence, regulatory compliance, and operational efficiency. The successful candidate will not only deliver results but also inspire and empower teams to achieve exceptional outcomes. About RIIRU: The Respiratory, Immunology and Inflammation Research Unit (RIIRU) was formed in 2024 to identify and advance novel molecular targets with genetic associations to disease based on the foundational observation that targets with human genetic evidence supporting their causal role in the intended indication improves clinical success by two-fold. The remit of RIIRU is to identify novel targets based on human genetics, develop assets for clinical studies, and perform trials through to submission for approvals. This goal is enabled through strategic external (e.g., Flagship Pioneering, Vesalius, Muna Therapeutics and others) and GSK-internal partnerships (Research Technologies). Please NOTE: This career opportunity requires an on-site office presence (minimum of two days a week) at one of GSK's US(PA or MA) or UK (Stevenage or London HQ) sites. Key Responsibilities Contribute to the clinical development strategy for a drug or program. Ensure execution of clinical development plans (CDP) for product(s) and/or indication(s) and provide strategic oversight and management of clinical trials. Lead clinical development activities from a therapeutic area and clinical trial perspective, including: Provide clinical and medical oversight of ongoing clinical trials Lead clinical trials and asset-level activities in a matrix team structure Identify and highlight transformational opportunities where projects can offer highly significant benefit to patients. Contribute to development of the Integrated Evidence Strategy (IES). Integrate scientific rationale, regulatory requirements, product development plans, and commercial goals to optimize asset indications and trials. Contribute to clinical development discussions and teams at global regulatory interactions. Draft clinical components of global regulatory submissions/files (e.g., IND, NDA, BLA, MAA), including briefing documents, presentations, and responses to regulatory questions. Promote innovative methodologies and processes including digital tools, encouraging others to think differently and adopt new ways of working. Stay abreast of advancements in therapeutic area research, clinical trial methodologies, competitive environment, and regulatory space to maintain GSK's competitive edge. Basic Qualifications Medical degree and clinical medical specialty training board qualification/registration in Internal Medicine or Primary Medical. Experience in the global pharmaceutical/biotechnology industry in the field of Hepatology. Experience in clinical research and drug development, with a focus on SLD, including ALD and MASH. Experience in late-stage Hepatology drug development, including Phase 2 and Phase 3 clinical trial design, initiation, execution, and closure. Experience in medical monitoring activities and oversight. Experience in leading regulatory submissions and managing global clinical trials. Experience with ICH and GCP guidelines and regulatory requirements Matrix team experience within a clinical development setting. Preferred Qualifications Medical degree and clinical medical specialty training board qualification/registration in Hepatology/Gastroenterology, Endocrinology or Nephrology. Thorough understanding of SLD, including ALD and MASH, the underlying biology and potential therapeutic targets. Solid understanding of needs and priorities of regulators, payers and prescribers in relevant global market(s). Track record of building and maintaining strong relationships with internal and external stakeholders. Demonstrated strong problem-solving skills and innovative thinking. Anticipate potential challenges, develop strategic approaches, and effectively communicate uncertainty to stakeholders while guiding teams through unclear circumstances. Have an enterprise mindset by identifying opportunities for synergy across the organization. Ability to use strategic thinking to analyze, interpret, and critically evaluate complex data and information. Anticipate obstacles and identify innovative solutions to ensure timely delivery of evidence that supports regulatory approvals and patient benefit. Navigate ambiguity by anticipating regulatory challenges and proactively addressing issues. Experience of clinical research methodology and principles of biostatistics to facilitate innovative and efficient designs of clinical trials and clinical development plans with clear data driven decision rules. • If you are based in Cambridge, MA; Waltham, MA; Rockville, MD; or San Francisco, CA, the annual base salary for new hires in this position ranges $284,625 to $474,375. • If you are based in another US location, the annual base salary range is $0 to $0. The US salary ranges take into account a number of factors including work location within the US market, the candidate's skills, experience, education level and the market rate for the role. In addition, this position offers an annual bonus and eligibility to participate in our share based long term incentive program which is dependent on the level of the role. Available benefits include health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave. If salary ranges are not displayed in the job posting for a specific country, the relevant compensation will be discussed during the recruitment process. Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees. Why GSK? Uniting science, technology and talent to get ahead of disease together. GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases to impact health at scale. People and patients around the world count on the medicines and vaccines we make, so we're committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people. Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us at where you can also request a call. Please note should your inquiry not relate to adjustments, we will not be able to support you through these channels. However, we have created a Recruitment FAQ guide. Click the link where you will find answers to multiple questions we receive. GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law. Important notice to Employment businesses/ Agencies GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site. . click apply for full job details

Job description Site Name: USA - Pennsylvania - Upper Providence, GSK HQ, UK - Hertfordshire - Stevenage, USA - Massachusetts - Waltham Posted Date: Jan GSK is seeking a highly skilled Senior Medical Director, Clinical Development, for an Advanced Pipeline Unit (APU) Hepatology group to provide clinical and scientific leadership for potential new, established and emerging indications for assets in clinical development with a strong focus on steatotic liver disease (SLD), including alcohol-associated liver disease (ALD). You will work with project teams to plan and ensure delivery of clinical research and development activities and establish efficient collaboration throughout all stages of development. You will report to the Senior Director/Clinical Development Lead for an asset in the SLD therapeutic area. This role is pivotal in driving GSK's mission to deliver transformative medicines to patients, ensuring clinical excellence, regulatory compliance, and operational efficiency. The successful candidate will not only deliver results but also inspire and empower teams to achieve exceptional outcomes. About RIIRU: The Respiratory, Immunology and Inflammation Research Unit (RIIRU) was formed in 2024 to identify and advance novel molecular targets with genetic associations to disease based on the foundational observation that targets with human genetic evidence supporting their causal role in the intended indication improves clinical success by two-fold. The remit of RIIRU is to identify novel targets based on human genetics, develop assets for clinical studies, and perform trials through to submission for approvals. This goal is enabled through strategic external (e.g., Flagship Pioneering, Vesalius, Muna Therapeutics and others) and GSK-internal partnerships (Research Technologies). Please NOTE: This career opportunity requires an on-site office presence (minimum of two days a week) at one of GSK's US(PA or MA) or UK (Stevenage or London HQ) sites. Key Responsibilities Contribute to the clinical development strategy for a drug or program. Ensure execution of clinical development plans (CDP) for product(s) and/or indication(s) and provide strategic oversight and management of clinical trials. Lead clinical development activities from a therapeutic area and clinical trial perspective, including: Provide clinical and medical oversight of ongoing clinical trials Lead clinical trials and asset-level activities in a matrix team structure Identify and highlight transformational opportunities where projects can offer highly significant benefit to patients. Contribute to development of the Integrated Evidence Strategy (IES). Integrate scientific rationale, regulatory requirements, product development plans, and commercial goals to optimize asset indications and trials. Contribute to clinical development discussions and teams at global regulatory interactions. Draft clinical components of global regulatory submissions/files (e.g., IND, NDA, BLA, MAA), including briefing documents, presentations, and responses to regulatory questions. Promote innovative methodologies and processes including digital tools, encouraging others to think differently and adopt new ways of working. Stay abreast of advancements in therapeutic area research, clinical trial methodologies, competitive environment, and regulatory space to maintain GSK's competitive edge. Basic Qualifications Medical degree and clinical medical specialty training board qualification/registration in Internal Medicine or Primary Medical. Experience in the global pharmaceutical/biotechnology industry in the field of Hepatology. Experience in clinical research and drug development, with a focus on SLD, including ALD and MASH. Experience in late-stage Hepatology drug development, including Phase 2 and Phase 3 clinical trial design, initiation, execution, and closure. Experience in medical monitoring activities and oversight. Experience in leading regulatory submissions and managing global clinical trials. Experience with ICH and GCP guidelines and regulatory requirements Matrix team experience within a clinical development setting. Preferred Qualifications Medical degree and clinical medical specialty training board qualification/registration in Hepatology/Gastroenterology, Endocrinology or Nephrology. Thorough understanding of SLD, including ALD and MASH, the underlying biology and potential therapeutic targets. Solid understanding of needs and priorities of regulators, payers and prescribers in relevant global market(s). Track record of building and maintaining strong relationships with internal and external stakeholders. Demonstrated strong problem-solving skills and innovative thinking. Anticipate potential challenges, develop strategic approaches, and effectively communicate uncertainty to stakeholders while guiding teams through unclear circumstances. Have an enterprise mindset by identifying opportunities for synergy across the organization. Ability to use strategic thinking to analyze, interpret, and critically evaluate complex data and information. Anticipate obstacles and identify innovative solutions to ensure timely delivery of evidence that supports regulatory approvals and patient benefit. Navigate ambiguity by anticipating regulatory challenges and proactively addressing issues. Experience of clinical research methodology and principles of biostatistics to facilitate innovative and efficient designs of clinical trials and clinical development plans with clear data driven decision rules. • If you are based in Cambridge, MA; Waltham, MA; Rockville, MD; or San Francisco, CA, the annual base salary for new hires in this position ranges $284,625 to $474,375. • If you are based in another US location, the annual base salary range is $0 to $0. The US salary ranges take into account a number of factors including work location within the US market, the candidate's skills, experience, education level and the market rate for the role. In addition, this position offers an annual bonus and eligibility to participate in our share based long term incentive program which is dependent on the level of the role. Available benefits include health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave. If salary ranges are not displayed in the job posting for a specific country, the relevant compensation will be discussed during the recruitment process. Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees. Why GSK? Uniting science, technology and talent to get ahead of disease together. GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases to impact health at scale. People and patients around the world count on the medicines and vaccines we make, so we're committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people. Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us at where you can also request a call. Please note should your inquiry not relate to adjustments, we will not be able to support you through these channels. However, we have created a Recruitment FAQ guide. Click the link where you will find answers to multiple questions we receive. GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law. Important notice to Employment businesses/ Agencies GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site. . click apply for full job details

A leading healthcare company is seeking a researcher to join their Responsible AI team. The role focuses on developing and publishing innovative AI/ML methods for drug discovery and clinical applications, emphasizing ethical considerations. Ideal candidates will hold a PhD or equivalent in a quantitative field and have a proven track record in ML research, particularly with large language models. This position offers the opportunity to contribute to groundbreaking healthcare solutions in a collaborative and dynamic environment. Applications close on 22nd January 2026.

Job description At GSK, we are using Artificial Intelligence (AI) and Machine Learning (ML) to develop new therapies and personalized drugs that drive better outcomes for patients at reduced cost with fewer side effects. Because the datasets we use and algorithms we build at each step of the drug development journey have safety and ethical implications for our patients, GSK has a dedicated team working on the responsible use of AI in healthcare. If this excites you and you want to be part of our team, we would love to chat. We are looking for a researcher with a track record in successfully developing and publishing state-of-the-art AI/ML methods, preferably with a focus on large language models (LLMs), LLM-based agents, and their evaluation. In addition to outstanding ML engineering and research skills, ideal candidates will demonstrate a keen interest in ethical and safety aspects of using AI in drug discovery and the clinic. The Responsible AI team is built on the principles of ownership, accountability, continuous development, and collaboration. We hire for the long term, and we are motivated to make this a great place to work. Our leaders will be committed to your career and development from day one. We strongly encourage applications from people with diverse and underrepresented backgrounds and perspectives. In this role you will Perform and publish ML research on the responsible use of AI agents in drug discovery and clinical applications. Develop state-of-the-art ML methods to solve applied problems at the interface of AI agents, drug discovery and challenging biomedical datasets. Support different teams across AIML and GSK in building ethical ML pipelines and software products. Work closely with research scientists, senior leaders, AI/ML engineers, and policy experts on the implementation of GSK's responsible AI strategy. Why you? Basic Qualifications: A PhD-equivalent degree in a quantitative or engineering discipline (e.g., computer science, computational biology, bioinformatics, engineering, among others); OR equivalent work experience as a professional ML research engineer. A track record of performing high quality ML research, evidenced by publications at major ML venues. A strong foundation in machine learning and experience with state-of-the-art modelling approaches, especially LLMs and LLM-based systems. Demonstrated programming expertise in Python and experience working with different types of complex and/or multi-modal datasets. Solid understanding of at least one major deep learning framework (PyTorch, TensorFlow). Keenness to learn fast in a new domain and to develop your ML and software engineering skills. Proactive communication and problem-solving, and a proven ability to collaborate with colleagues of various backgrounds and levels of seniority. Preferred Qualifications: Experience working with biomedical data (e.g., genomics, transcriptomics, proteomics, electronic health records, clinical images). Contributions to relevant open-source projects. A background or interest in drug discovery, biology, medicine or ethics. Closing Date for Applications: Thursday 22nd January 2026 (COB) Please take a copy of the Job Description, as this will not be available post closure of the advert. When applying for this role, please use the 'cover letter' of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application. During the course of your application, you will be requested to complete voluntary information which will be used in monitoring the effectiveness of our equality and diversity policies. Your information will be treated as confidential and will not be used in any part of the selection process. If you require a reasonable adjustment to the application / selection process to enable you to demonstrate your ability to perform the job requirements, please contact . This will help us to understand any modifications we may need to make to support you throughout our selection process. GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law. We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are. Please note that your enquiry related to adjustments must be directed to . The recruitment FAQ guide is available online for additional questions.