SLS Services Limited

A growing biotechnology company in the UK is seeking a Process Development Scientist to enhance cell and gene therapy initiatives. The role focuses on Upstream Processing and involves project management, collaboration with stakeholders, and extensive laboratory work. Ideal candidates should have relevant experience in bioprocessing, particularly upstream processing technologies, and hold a PhD or BSc with substantial industrial experience. This position presents an excellent opportunity for career development in the biotechnology field.

Are you passionate about Quality Control, with expertise in Molecular Biology, Cell Biology, or Stem Cell Biology? Do you have significant industry experience in Quality Control for Advanced Therapies, particularly within Cell and Gene Therapy? If so, this could be a unique opportunity for an ambitious individual to join a rapidly growing organization focused on cutting-edge stem cell innovation. The Role: As a Senior Scientist, you will report to the Associate Director of QC & GMP Analytical Development and will be responsible for implementing QC testing for cell banks, starting materials, drug substance, and drug product to support clinical manufacturing of a cell therapy candidate. This is an exciting opportunity to contribute to the development of next generation cell therapies, collaborating with teams across quality, regulatory, and CMC. Key responsibilities include: Leading method transfer, establishment, and qualification of assays for QC release of a novel engineered cell therapy, including flow cytometry, ddPCR and/or qPCR, and cell based functional assays. Participating in the selection of contract testing organizations (CTOs) and contract development and manufacturing organizations (CDMOs) for analytical methods required for testing starting materials, drug substance, and drug product. Collaborating with the analytical development team to ensure method readiness for transfer to GMP testing labs. Working with quality assurance and regulatory teams to incorporate current regulations and guidance into the testing approach. Skills and Experience Required: Strong experience in Quality Control, ideally within a Biologics, Cell Therapy/ATMP, or Biopharmaceutical organization. Solid understanding of qPCR or ddPCR. Educational background in Molecular Biology, Cell Biology, Biological Science, Stem Cell Biology, or a related field. Excellent communication skills and the ability to work with individuals at all levels. Proactive, driven, pragmatic, open minded, emotionally intelligent, and respectful approach to work. Benefits: Competitive salary. Opportunity to work on cutting edge therapies and technologies in a growing field. Dynamic, cross functional work environment that encourages collaboration. This is a permanent position offering the chance to contribute to the development of next generation cell therapies in a fast paced, innovative environment.

A growing biotechnology company is seeking a Process Development Scientist to advance the growth of cell and gene therapy. This position focuses on Upstream Processing (USP) and process characterisation for ATMPs (Advanced Therapy Medicinal Products) using innovative Process Analytical Technologies (PAT). The role involves working collaboratively with internal and external stakeholders, managing both commercial and collaborative biomarker discovery, process characterisation, and development projects. Key Responsibilities: Collaborate with cross-functional teams to scope, plan, and deliver USP process characterisation and biomarker discovery projects. Apply knowledge of USP bioprocessing, PAT, and data analysis techniques to drive project success. Provide subject matter expertise in laboratory work, ATMP-related products, processes, and technical report preparation. Lead laboratory activities associated with USP and Biomarker discovery projects, including stock control, experimental design, and compliance with onsite procedures. Support and communicate effectively with internal and external stakeholders to disseminate new USP and PAT capabilities. Produce experimental plans, review data integrity, and ensure adherence to company policies. Present data at conferences and meetings, as appropriate. Plan and execute experiments to meet project deliverables and timelines. Work with technology providers to ensure leadership in USP and PAT technology development. Required Skills: Experience in bioprocessing, particularly upstream processing using STR and other cell culture technologies (e.g., DASbox, BioBLU, ambr250, Univessel). Knowledge of AAV or iPSC culture processes is a plus. Experience with standard analytical assays such as flow cytometry, PCR, metabolite analysis, and cell counting is desirable. Familiarity with statistical tools, method validation, and Design of Experiments (DoE) for experimental design. Experience in integrating PAT technologies into bioprocessing workflows is beneficial. Proficiency in data handling and Microsoft Excel and Word. PhD or BSc with 3+ years of industrial experience in life sciences or bioengineering (or equivalent qualifications). This is a great opportunity to work on cutting-edge technology within the biotechnology sector, with potential for career growth and development.