Immunocore

Job Details: Scientist- Bioinformatician Full details of the job. Location of role UK Department Translational Medicine Key Responsibilities MAIN PURPOSE OF JOB: To provide focused bioinformatics support to Translational Medicine teams. This individual will support the analysis and data management of translational biomarker data with appropriate guidance from colleagues and managers. Conduct the analysis of transcriptomic and genomic sequencing data from our clinical trials. Analyse in vitro data generated by the Translational Medicine laboratory group. Compliment and develop our scientific hypotheses through the mining of public data and the design and analysis of our own in-house experiments. Identify new data sources and analytic solutions to support Translational Medicine projects. Develop custom made tools and analytics to assist interpretation and data visualisation. Contribute to abstracts and manuscripts as required. Maintain and increase technical knowledge in relevant fields through self study, observation, attending relevant conferences and training courses. Maintain accurate records of all work by completing documentation on time, following Company procedures. Operate in accordance with the Company's Health and Safety policies. Experience and Knowledge Essential Will be proficient in R/BioConductor, Linux OS and shell scripting bash. Proven programming ability. Understanding of molecular biology, cell biology, immunology or related discipline. Presented detailed scientific findings and papers to internal and external audiences. Must be able to communicate on a technical level with other scientists from unrelated disciplines. Self motivated; demonstrated success in delivering assigned tasks according to timelines. Ability to think outside the box and problem solve. Enjoy working in a fast paced environment as part of a motivated team. Desirable Experience of independent research in academic or industrial setting, or transferable skills gained from professional experience. Background in running NGS analysis pipelines. Experience in developing R Shiny apps. May have experience of developing databases, using SQL or similar, and pairing with a user friendly interface. Mentored and coached less experienced colleagues in scientific practices and theory. May have knowledge of machine learning, applied statistics or related field. Education & Qualifications PhD in a bioinformatics discipline with 0 2 years' experience; may include post doctoral experience. Or MSc degree or BSc with equivalent, relevant experience. About the Company Immunocore (NASDAQ: IMCR) is a pioneering, commercial stage T cell receptor biotechnology company whose purpose is to develop and commercialize a new generation of transformative medicines which address unmet patient needs in oncology, infectious diseases and autoimmune disease. Our leaders in R&D are internationally recognised as some of the biotech industry's most successful drug developers. We are creating not just an environment where great minds can interact but an innovation powerhouse answering the big questions. Focused on delivering first in class biological therapies to patients, we have developed a highly innovative soluble TCR platform. Our ImmTAX molecules underpin a new generation of precision engineered drugs that harness the immune system to treat a broad spectrum of diseases with high unmet medical need, including oncology, infectious diseases and autoimmune diseases. At Immunocore, we recognize that our employees are our greatest asset. We value the unique contributions each person brings to our team. By embracing Science, Trust, Respect, Integrity, Diversity, and Entrepreneurship (STRIDE), we create an environment where collaboration thrives, ideas flourish, and transformative changes happen. STRIDE represents more than just letters; it embodies our shared identity and drives our mission. We are dedicated to developing breakthrough therapies that transform patients' lives, advancing medicine, and supporting one another in these pursuits. Immunocore is proud to be an equal opportunity employer. As such, we are committed to fostering an inclusive workplace where everyone feels valued, respected, and empowered. We encourage applications from individuals of all backgrounds, regardless of race, color, religion, sex, sexual orientation, gender identity or expression, pregnancy, age, national origin, disability status, or any other characteristic protected by law.

Job Details: Senior Scientist I - Analytical Development & Validation Full details of the job. Vacancy Name Vacancy Name Senior Scientist I - Analytical Development & Validation Vacancy No Vacancy No VN627 Employment Type Employment Type Permanent Location of role Location of role Oxford, UK Department Department CMC Key Responsibilities To conduct and design experimental investigations enabling the advancement of the Company pipeline, process, or technology capabilities, proposing improvements for consideration by colleagues and managers. To perform assay development and qualification for ImmTAX and other TCR based molecules and oversee method transfers to CDMOs. Designing and conducting chromatographic, electrophoretic and immunoassay development studies to support stability and release of ImmTAC and other TCR based molecules. Supporting qualification of chromatographic, electrophoretic and immunoassay methods (according to ICH guidelines) to allow release testing of the company drug molecules. Contributing to method transfers to contract development and manufacturing organisations (CDMO). Leading investigational, CMC supportive packages and comparability studies of biologics/drug products. Writing study protocols and reports. Independently testing and, increasingly, leading lines of investigation. Proposing new experiments based on emerging data and other related information. Providing support on technical aspects to others. Priorities: establishing priorities for own work and team-based projects; making decisions on prioritisation based on the overall goals of the team, department and project, using direct evidence and personal experience as guidance. Technical Knowledge: sharing knowledge with the wider team and, across departments representing the department both internally and externally. May also act as a mentor or manager to other colleagues, especially new hires, sharing scientific and company knowledge. Increasingly providing analysis of new techniques and theories from outside the Company to advance the way the company works; sharing these with leaders across the Company. Laboratory records: ensuring that all records and information are up to date, on time and recorded to the correct standard. Supporting and encouraging others to achieve this. Laboratory equipment: providing technical guidance to others within the team on how to use equipment most effectively; making recommendations regarding acquisition of new pieces of equipment. Reporting: communicating and presenting research findings at meetings with colleagues, senior management and partners. Adhere to safe working practices in laboratories according to Immunocore EHS policies. Person Specification Experience & knowledge Essential Experience in development of chromatographic and electrophoretic methods used in the analysis of recombinant proteins or antibodies. Worked in a bench-based biopharmaceutical laboratory environment. Established as an expert amongst peers in one or more of the following areas: electrophoretic, chromatographic, immuno-analytical. Experienced in assay qualification/validation and/ or system suitability i.e. robustness analytical limits. Familiar with biopharmaceutical stability study principles and interpretation thereof. Worked and contributed actively in a diverse team environment. Proposed and driven changes in working practices that have improved efficiency, supported teams through adoption and change. Presented detailed scientific findings and papers to internal and external audiences. Mentored and coached less experienced colleagues in scientific practices and theory. Desirable Experience with late stage/commercial biopharmaceutical assay development and characterisation. Familiar with the principles of Good Manufacturing Practise (GMP). Presented papers at external conferences. Participated in external scientific experiments and/or analytical collaborations. Led a small project team, formally or informally, through a change in practice including project management. Understanding of analytical requirements to support materials for use in clinical trials. Education & qualifications Essential: BSc. Or MSc. in biochemistry, biotechnology or related discipline. Desirable: PhD in related discipline. About the Company Immunocore (NASDAQ: IMCR) is a pioneering, commercial-stage T cell receptor biotechnology company whose purpose is to develop and commercialize a new generation of transformative medicines which address unmet patient needs in oncology, infectious diseases and autoimmune disease. Our leaders in R&D are internationally recognised as some of the biotech industry's most successful drug developers. We are creating not just an environment where great minds can interact but an innovation powerhouse answering the big questions. Focused on delivering first-in-class biological therapies to patients, we have developed a highly innovative soluble TCR platform. Our ImmTAX molecules underpin a new generation of precision engineered drugs that harness the immune system to treat a broad spectrum of diseases with high unmet medical need, including oncology, infectious diseases and autoimmune diseases. At Immunocore, we recognize that our employees are our greatest asset. We value the unique contributions each person brings to our team. By embracing Science, Trust, Respect, Integrity, Diversity, and Entrepreneurship (STRIDE), we create an environment where collaboration thrives, ideas flourish, and transformative changes happen. STRIDE represents more than just letters; it embodies our shared identity and drives our mission. We are dedicated to developing breakthrough therapies that transform patients' lives, advancing medicine, and supporting one another in these pursuits. Immunocore is proud to be an equal opportunity employer. As such, we are committed to fostering an inclusive workplace where everyone feels valued, respected, and empowered. We encourage applications from individuals of all backgrounds, regardless of race, color, religion, sex, sexual orientation, gender identity or expression, pregnancy, age, national origin, disability status, or any other characteristic protected by law.

Overview Job Details: Senior Scientist II Analytical Development - Bioprocess Analytics. Full details of the job. Vacancy Name Senior Scientist II Analytical Development - Bioprocess Analytics Vacancy No VN690 Employment Type Full Time Location Oxford, UK Department CMC Responsibilities Contribute to analytical program strategies across the therapeutic project portfolio. Represent analytical development within cross-functional project teams, providing strategic support and technical consultancy. Lead development of robust impurity analytical methods to support effective development of the Immunocore therapeutic drug portfolio, including methods such as host cell protein ELISA, 2D Western blotting, host cell DNA and/or endotoxin assays as well as HPLC of residual impurities. Lead development and oversight of product and process impurity control strategy and characterisation in aid of product development. Oversee technical transfer and validation of assays at contract manufacturers in line with ICH regulatory guidelines, and develop phase appropriate specifications. Support digital transformation project in defining key analytical outputs and identify methods to streamline data handling. Develop scientists of lower grades within the analytical development team. Prepare reports and presentations of high quality suitable for internal and external audiences. Be a lead author of relevant sections of CMC regulatory documentation, e.g., IND, IMPD, BLA, MAA and responses to any agency questions. Keep abreast of developments in area of expertise to advance company activities where deemed appropriate; providing in-depth analysis of new techniques and theories to advance the way the company works, raising and championing these with leaders and colleagues across the company. Review competing priorities for projects and provide clear and thorough recommendations, considering the overall goals of the project, department and company. Implement safe working practices in laboratories for the team according to Immunocore EHS policies. Qualifications Experience & knowledge Essential Strong knowledge of large molecule analytical science. Expert in analytical method development in support of impurity assessment of biopharmaceutical drug candidate development. Expertise in at least two of the following: host cell protein ELISA, 2D Western blotting, HPLC of residual impurities or endotoxin assays. Experienced in process-related impurity characterisation and control for biologic drug molecules. Experienced in phase-appropriate assay validation. Strong track record of collaborating on projects with a team. Excellent communicator that proactively interacts with cross-functional stakeholders. Presented detailed scientific findings to internal and external audiences. Mentored and coached less experienced colleagues in scientific practices and theory. Owned, participated and provided input to regulatory submission documentation and discussions. Desirable Experience with Charge Aerosol Detector HPLC methods. Experience with low endotoxin recovery. Experience with extractable & leachable assessments. Bioinformatics and data management experience in a CMC setting. Built a network of external scientific contacts as both a contributor and recipient. Contributed to and influenced the strategic scientific direction within the CMC department and company on the whole. Relevant experience with people line-management in biopharmaceutical industry. Education & qualifications Essential: BSc. Or MSc. in biochemistry, molecular biology or related discipline. Desirable: PhD in related discipline. About the Company Immunocore (NASDAQ: IMCR) is a pioneering, commercial-stage T cell receptor biotechnology company whose purpose is to develop and commercialize a new generation of transformative medicines which address unmet patient needs in oncology, infectious diseases and autoimmune disease. Our leaders in R&D are internationally recognised as some of the biotech industry's most successful drug developers. We are creating not just an environment where great minds can interact but an innovation powerhouse answering the big questions. Focused on delivering first-in-class biological therapies to patients, we have developed a highly innovative soluble TCR platform. Our ImmTAX molecules underpin a new generation of precision engineered drugs that harness the immune system to treat a broad spectrum of diseases with high unmet medical need, including oncology, infectious diseases and autoimmune diseases. At Immunocore, we recognize that our employees are our greatest asset. We value the unique contributions each person brings to our team. By embracing Science, Trust, Respect, Integrity, Diversity, and Entrepreneurship (STRIDE), we create an environment where collaboration thrives, ideas flourish, and transformative changes happen. STRIDE represents more than just letters; it embodies our shared identity and drives our mission. We are dedicated to developing breakthrough therapies that transform patients' lives, advancing medicine, and supporting one another in these pursuits. Immunocore is proud to be an equal opportunity employer. As such, we are committed to fostering an inclusive workplace where everyone feels valued, respected, and empowered. We encourage applications from individuals of all backgrounds, regardless of race, color, religion, sex, sexual orientation, gender identity or expression, pregnancy, age, national origin, disability status, or any other characteristic protected by law.

Senior Scientist - Assay Development & High-throughput Screening FTC 7 months Location: Oxford, UK Responsibilities The primary purpose of this role is to leverage a strong working knowledge of biologics assay development and high-throughput screening to solve day to day problems while developing expertise in related areas. The role involves responsibility for developing and implementing high throughput, automated cell assays for the discovery of transformative T cell engager medicines. In addition to identifying and building innovative, state of the art assays to identify and assess the functional properties of potential candidate therapeutics, the role will involve liaising with Drug Discovery and automation scientists to streamline drug discovery. Independently identify, design, develop, and validate state of the art cell assays for assessment of target binding and functional properties of T cell engager molecules. Work alongside automation experts to build, optimise and implement high throughput cell binding assay capabilities. Analyse, interpret and effectively communicate experimental results, recommendations and plans to project teams. Maintain a good understanding of state of the art and emerging biologics drug formats and the assays used for characterisation. Contribute to identifying, evaluating, building, and applying innovative cell assays and streamlining drug discovery processes. Troubleshoot and identify resourceful, relevant solutions for complex scientific challenges. Contribute to internal and external collaborations. Provide technical training to team members where required. Follow Good Laboratory Practice and adhere to Immunocore health and safety policies. Education and Experience Essential Qualifications Normally requires a PhD in a scientific discipline and a minimum of 2 5 years related experience; may include post doctoral experience. Or MSc degree or BSc degree with extensive role specific equivalent research or industrial experience. Essential Experience, Knowledge & Abilities Experienced in performing biologics assays. Experienced in use of automation e.g. liquid handlers. Experienced in use of functional cell assays for biologics. Track record of solving scientific problems creatively. Track record of collaborating and contributing as a project team member. Effective communication of scientific concepts and findings. Preferred Experience, Knowledge & Abilities Experience in scripting and troubleshooting of automation systems. Experience with high throughput screening methodologies. Experience in biologics drug discovery. Track record of evaluating innovative solutions to improve processes. Other Attention to detail and quality. Strong organisation skills with ability to plan, prioritise and coordinate work with others. Strong team player with ability to actively listen and work productively with other team members in a matrix environment. Ability to communicate clearly to relevant audiences. Demonstrates innovative thinking. About the Company Immunocore (NASDAQ: IMCR) is a pioneering, commercial stage T cell receptor biotechnology company whose purpose is to develop and commercialise a new generation of transformative medicines which address unmet patient needs in oncology, infectious diseases and autoimmune disease. Our leaders in R&D are internationally recognised as some of the biotech industry's most successful drug developers. We are creating not just an environment where great minds can interact but an innovation powerhouse answering the big questions. Focused on delivering first in class biological therapies to patients, we have developed a highly innovative soluble TCR platform. Our ImmTAX molecules underpin a new generation of precision engineered drugs that harness the immune system to treat a broad spectrum of diseases with high unmet medical need, including oncology, infectious diseases and autoimmune diseases. At Immunocore, we recognise that our employees are our greatest asset. We value the unique contributions each person brings to our team. By embracing Science, Trust, Respect, Integrity, Diversity, and Entrepreneurship (STRIDE), we create an environment where collaboration thrives, ideas flourish, and transformative changes happen. STRIDE represents more than just letters; it embodies our shared identity and drives our mission. We are dedicated to developing breakthrough therapies that transform patients' lives, advancing medicine, and supporting one another in these pursuits. Immunocore is proud to be an equal opportunity employer. As such, we are committed to fostering an inclusive workplace where everyone feels valued, respected, and empowered. We encourage applications from individuals of all backgrounds, regardless of race, colour, religion, sex, sexual orientation, gender identity or expression, pregnancy, age, national origin, disability status, or any other characteristic protected by law.

A biotechnology company in Oxford is seeking a Principal Formulation Development Scientist I to lead formulation development for innovative bio-pharmaceuticals. Candidates should have a PhD and extensive experience in drug delivery strategies, recombinant protein formulation, and analytical techniques. This role involves hands-on laboratory work, collaboration with CMC teams, and management responsibilities in a dynamic environment focused on innovation. The successful applicant will contribute to the development of transformative medicines addressing significant patient needs.

A leading biotechnology company in Oxford seeks a Senior Scientist to develop high-throughput automated assays for T cell engager medicines. Responsibilities include designing and validating cell assays, collaborating on drug discovery, and troubleshooting scientific challenges. Candidates should hold a PhD in a scientific discipline and demonstrate experience in biologics and assay development. This role offers an opportunity to work in a pioneering environment focused on innovative therapies.

Job Details: Principal Formulation Development Scientist I Full details of the job. Vacancy Name Vacancy Name Principal Formulation Development Scientist I Vacancy No Vacancy No VN705 Employment Type Employment Type Permanent Location of role Location of role Oxford, UK Department Department CMC Key Responsibilities The primary purpose of this role is to serve as a recognized technical leader in formulation development, leveraging extensive experience and expert knowledge to drive innovation and contribute to the company's scientific strategy. The incumbent is expected to advocate for process, platform, and technology improvements, and apply advanced knowledge of scientific principles and the drug development process to solve extremely complex problems. The individual will exercise independent judgment in developing methods and techniques, consistently making the right calls to achieve results. This position will be responsible for conducting and designing experimental investigations to support a low & high dose parenteral bio pharmaceutical in the development and management of integrated formulation strategies supporting Immunocore's bio pharmaceutical platforms. The formulation role will be a hands on role, primarily focussed on lab work designing and performing experimental work. It will also cover drug delivery approaches, investigate novel technologies such as LNP, Pegylation and other delivery systems applicable to biologicals. The role will also cover early stressing studies, formulation excipient screening, CMC process support, drug substance and drug product through to compatibility with final patient delivery systems. Support and direct IUS studies and progress the clinical programmes. Support and respond to main stakeholders, for example Clinical and Regulatory teams, in the delivery of the clinical strategies. To work in close collaboration with the Head of Formulation, CMC teams and related functions to input into the formulation related sections for regulatory filings, development reports and other development related documents. Advanced people management skills are essential, including managing changing priorities while maintaining team motivation. They will create a safe environment for learning from mistakes, establish clear career paths, and hold career development conversations. The individual will engage in difficult conversations where appropriate, inspire action, and show employees how they contribute to higher goals. Conducting experiments, observing, interpreting and responding to results. Maintaining and increasing technical knowledge in relevant fields through self study, observation, attending relevant conferences and training courses. Maintaining accurate records of all work by completing laboratory notebooks on time, following Company procedures. Ensuring that laboratory equipment is operated in accordance with safety and risk guidelines; acting promptly to report any faults or problems to the relevant member of staff. Operating in accordance with the Company's Health and Safety policies, especially within a laboratory environment. Specific Responsibilities Experiments: independently testing and, increasingly, leading lines of investigation. Proposing new experiments based on emerging data and other related information. Providing support on technical aspects to others. Specifically: Develop drug delivery approaches for the biologics portfolio. Bring in new technologies exploring new administration approaches. To conduct and design experiments to establish formulations for TCR platform API and IMP. Lead and direct pre formulation, cycle 1,2 and 3 activities. Conduct drug presentation studies to evaluate alternative drug administration routes (e.g. sub cut). Represent formulation in CMC teams. Investigate compatibility of drug product through delivery devices for patient administration. Investigations in novel drug delivery formats. Perform testing and develop test methods to support stability and formulation studies. Carry out and optimise production of recombinant protein supportive reagents, including conjugations. Communicate key findings to managers and scientists in other groups. Review/sign off of routine assays. Writing of SOPs. Contributing to regulatory documentation. Participation in laboratory maintenance. Perform IUS studies. Perform clinical compatibility studies. Direct investigations into IUS clinical site excursion event impacts. Identify new external scientific technology and collaborations. Introduce new science into the group. Hand on practical role. Priorities: establishing priorities for own work and team based projects; making decisions on prioritisation based on the overall goals of the team, department and project, using direct evidence and personal experience as guidance. Technical Knowledge: sharing knowledge with the wider team and across departments representing the department both internally and externally. May also act as a mentor or manager to other colleagues, especially new hires, sharing scientific and company knowledge. Increasingly providing analysis of new techniques and theories from outside the Company to advance the way the company works; sharing these with leaders across the Company. Laboratory records: ensuring that all records and information are up to date, on time and recorded to the correct standard. Supporting and encouraging others to achieve this. Laboratory equipment: providing technical guidance to others within the team on how to use equipment most effectively; making recommendations regarding acquisition of new pieces of equipment. Health & Safety: championing and helping others to understand H&S within the company, providing ad hoc training as required. Reporting: communicating and presenting research findings at meetings with colleagues, senior management and partners. Experience and Knowledge Essential Background in recombinant protein or antibody formulation, drug delivery of biologics, analytical development or protein characterisation, with proven industry experience and exposure to formulation strategies. Experience in design of formulation studies, including the utilisation of design of experiments principles. Strong expertise in electrophoretic or chromatographic assays and general biochemical lab techniques. Desirable Experience of process development for production of biologics and conjugation of biomolecules. Experience with lyophilisation development of Biotherapeutics. Familiar with biopharmaceutical stability study principles. Familiarity with novel drug delivery formats. Proactive in ensuring high quality of their work and seeking additional responsibilities to help meet the goals of the team. Presented detailed scientific findings and papers to internal and external audiences. Essential Qualifications PhD in bio manufacturing, protein engineering, biochemistry, molecular biology or related discipline. Industrial company experience delivering formulations through drug development phases. Normally requires a PhD in a scientific discipline and a minimum of 8+ years related experience; may include post doctoral experience. About the Company Immunocore (NASDAQ: IMCR) is a pioneering, commercial stage T cell receptor biotechnology company whose purpose is to develop and commercialise a new generation of transformative medicines which address unmet patient needs in oncology, infectious diseases and autoimmune disease. Our leaders in R&D are internationally recognised as some of the biotech industry's most successful drug developers. We are creating not just an environment where great minds can interact but an innovation powerhouse answering the big questions. Focused on delivering first in class biological therapies to patients, we have developed a highly innovative soluble TCR platform. Our ImmTAX molecules underpin a new generation of precision engineered drugs that harness the immune system to treat a broad spectrum of diseases with high unmet medical need, including oncology, infectious diseases and autoimmune diseases. At Immunocore, we recognise that our employees are our greatest asset. We value the unique contributions each person brings to our team. By embracing Science, Trust, Respect, Integrity, Diversity, and Entrepreneurship (STRIDE), we create an environment where collaboration thrives, ideas flourish, and transformative changes happen. STRIDE represents more than just letters; it embodies our shared identity and drives our mission. We are dedicated to developing breakthrough therapies that transform patients' lives, advancing medicine, and supporting one another in these pursuits. Immunocore is proud to be an equal opportunity employer. As such, we are committed to fostering an inclusive workplace where everyone feels valued, respected, and empowered. We encourage applications from individuals of all backgrounds, regardless of race, color, religion, sex, sexual orientation, gender identity or expression, pregnancy, age, national origin, disability status, or any other characteristic protected by law.