Cancer Research UK
Bearsden, Dunbartonshire
200 staff. Limitless Potential. One team. Cancer Research Horizons. Senior Scientist (Protein Sciences - Small Molecule) £41,700 - £51,300 plus benefits Department: Therapeutic Innovation, R&I Reports to: Principal Scientist Location : CRUK Scotland Institute, Glasgow with Low flex (Lab Based) Contract type/hours: Permanent Contract, Full time 35 hours per week Closing date: Friday 1st May :55pm Interview Date: Approximately week commencing 11th May Interview process: Competency based interview with task/presentation At Cancer Research UK, we exist to beat cancer. We have an exciting opportunity for a Senior Scientist in Protein Sciences to join Cancer Research Horizons in our Glasgow lab. You'll lead the expression, purification and QC of protein antigens and related molecules (small molecule drug discovery focus), all of which play a critical role in driving our screening and crystallography programmes. Working primarily across bacterial and insect systems, you'll deliver high quality, well characterised proteins using a range of biochemical and biophysical methods. You'll collaborate closely with multidisciplinary drug discovery teams, communicate insights clearly, drive strategic decisions, innovate across the existing pipeline, bring strong scientific leadership the team, and help ensure a safe, efficient lab environment. You'll collaborate closely with multi disciplinary teams, communicate insights clearly, maintain high quality electronic records and help ensure a safe, efficient lab environment. We're looking for candidates with a PhD (or equivalent experience) in Molecular/Protein Sciences, Chemistry with substantial drug discovery experience, with strong protein production and molecular biology expertise. This is a high impact role that advances our discoveries. If you're adaptable, driven, and ready to make a scientific impact, this is your chance to contribute. Every role at CRH is united by a single mission: beating cancer sooner. We carry out work that matters - impacting patients, families, and the future of science. discovery experience, with strong molecular biology, protein purification based expertise. About Cancer Research Horizons As the world's biggest medical research charity, we've helped bring eleven new cancer drugs to market. However, there is still an urgent need to bring more effective treatments to patients faster. We have recently developed a new approach to driving therapeutic innovation through the creation of Cancer Research Horizons (CRH). We have brought together Cancer Research UK's established drug discovery teams under one organisation and leadership team, combining our unique pipeline of cancer biology expertise and access to CRUK's world-class academic network, cutting edge technology platforms and clinical expertise to 1) Bring new treatments to patients faster and 2) Tackle the biggest challenges in discovering cancer drugs by seeking out more radical ideas and embracing risk in our bid to achieve success. Based at sites in Cambridge, the CRUK Scotland Institute in Glasgow, and Newcastle University, you'll be joining over 200 staff from both industrial and academic backgrounds, all dedicated to bringing forward the day we cure cancer. What will you be doing? Expression and purification of recombinant proteins using bacterial and insect systems to support screening and crystallography programmes Ensure all production is sufficiently characterised and QC'd using appropriate biochemical and biophysical methods Interpret, analyse and clearly summarise data for presentation to varied audiences Work collaboratively within multi disciplinary research teams Communicate effectively, demonstrating openness and respect for others' perspectives Prioritise workload according to project objectives and take responsibility for timely delivery Drive scientific and technical innovation, including through internal and external collaborations, while staying current with developments in the field Maintain accurate and up to date electronic laboratory notebook records Take responsibility for assigned laboratory equipment and associated duties Uphold safe, compliant and effective working practices What are we looking for? PhD or equivalent in Molecular Sciences, Protein Sciences, Chemistry or significant experience within a drug discovery environment Significant experience in providing protein production & molecular biology expertise to enable drug discovery projects Ability to work in a fast-paced, quickly changing environment, showing agility/flexibility to meet deadlines and goals with a can-do attitude Use of current molecular biology techniques (PCR, cloning) to construct expression vectors and isolate genes Purification of tagged and native proteins via manual, AKTA and automated purification platforms using a range of chromatographic techniques Protein analytical techniques - e.g. protein quantitation assays, SDS-PAGE analysis, HPLC, Western Blotting and protein modifications e.g. biotinylation Track record of delivering results across a diverse project portfolio by leading and driving strategic and scientific initiatives Our organisation values are designed to guide all that we do. Bold: Act with ambition, courage and determination Credible: Act with rigour and professionalism Human : Act to have a positive impact on people Together: Act inclusively and collaboratively We're looking for people who can believe in and embody these organisation values and can use them to drive forward progress against our mission to beat cancer. If you're interested in applying and excited about working with us but are unsure if you have the right skills and experience, we'd still love to hear from you. What will I gain? We create a working environment that supports your wellbeing and provide a generous benefits package, a wide range of career and personal development opportunities and high-quality tools. Our policies and processes enable you to improve your work-life balance, take positive steps in your career and achieve your personal wellbeing goals. You can explore our benefits by visiting our careers web page. How do I apply? We operate an anonymised shortlisting process in our commitment to equality, diversity and inclusion. CVs are required for all applications; but we won't be able to view them until we invite you for an interview. Instead, we ask you to complete the work history section of the online application form for us to be able to assess you fairly and objectively. For more information on this career opportunity please visit our website or contact us. For more updates on our work and careers, follow us on: Linked In, Facebook, Instagram, X and YouTube.
200 staff. Limitless Potential. One team. Cancer Research Horizons. Senior Scientist (Protein Sciences - Small Molecule) £41,700 - £51,300 plus benefits Department: Therapeutic Innovation, R&I Reports to: Principal Scientist Location : CRUK Scotland Institute, Glasgow with Low flex (Lab Based) Contract type/hours: Permanent Contract, Full time 35 hours per week Closing date: Friday 1st May :55pm Interview Date: Approximately week commencing 11th May Interview process: Competency based interview with task/presentation At Cancer Research UK, we exist to beat cancer. We have an exciting opportunity for a Senior Scientist in Protein Sciences to join Cancer Research Horizons in our Glasgow lab. You'll lead the expression, purification and QC of protein antigens and related molecules (small molecule drug discovery focus), all of which play a critical role in driving our screening and crystallography programmes. Working primarily across bacterial and insect systems, you'll deliver high quality, well characterised proteins using a range of biochemical and biophysical methods. You'll collaborate closely with multidisciplinary drug discovery teams, communicate insights clearly, drive strategic decisions, innovate across the existing pipeline, bring strong scientific leadership the team, and help ensure a safe, efficient lab environment. You'll collaborate closely with multi disciplinary teams, communicate insights clearly, maintain high quality electronic records and help ensure a safe, efficient lab environment. We're looking for candidates with a PhD (or equivalent experience) in Molecular/Protein Sciences, Chemistry with substantial drug discovery experience, with strong protein production and molecular biology expertise. This is a high impact role that advances our discoveries. If you're adaptable, driven, and ready to make a scientific impact, this is your chance to contribute. Every role at CRH is united by a single mission: beating cancer sooner. We carry out work that matters - impacting patients, families, and the future of science. discovery experience, with strong molecular biology, protein purification based expertise. About Cancer Research Horizons As the world's biggest medical research charity, we've helped bring eleven new cancer drugs to market. However, there is still an urgent need to bring more effective treatments to patients faster. We have recently developed a new approach to driving therapeutic innovation through the creation of Cancer Research Horizons (CRH). We have brought together Cancer Research UK's established drug discovery teams under one organisation and leadership team, combining our unique pipeline of cancer biology expertise and access to CRUK's world-class academic network, cutting edge technology platforms and clinical expertise to 1) Bring new treatments to patients faster and 2) Tackle the biggest challenges in discovering cancer drugs by seeking out more radical ideas and embracing risk in our bid to achieve success. Based at sites in Cambridge, the CRUK Scotland Institute in Glasgow, and Newcastle University, you'll be joining over 200 staff from both industrial and academic backgrounds, all dedicated to bringing forward the day we cure cancer. What will you be doing? Expression and purification of recombinant proteins using bacterial and insect systems to support screening and crystallography programmes Ensure all production is sufficiently characterised and QC'd using appropriate biochemical and biophysical methods Interpret, analyse and clearly summarise data for presentation to varied audiences Work collaboratively within multi disciplinary research teams Communicate effectively, demonstrating openness and respect for others' perspectives Prioritise workload according to project objectives and take responsibility for timely delivery Drive scientific and technical innovation, including through internal and external collaborations, while staying current with developments in the field Maintain accurate and up to date electronic laboratory notebook records Take responsibility for assigned laboratory equipment and associated duties Uphold safe, compliant and effective working practices What are we looking for? PhD or equivalent in Molecular Sciences, Protein Sciences, Chemistry or significant experience within a drug discovery environment Significant experience in providing protein production & molecular biology expertise to enable drug discovery projects Ability to work in a fast-paced, quickly changing environment, showing agility/flexibility to meet deadlines and goals with a can-do attitude Use of current molecular biology techniques (PCR, cloning) to construct expression vectors and isolate genes Purification of tagged and native proteins via manual, AKTA and automated purification platforms using a range of chromatographic techniques Protein analytical techniques - e.g. protein quantitation assays, SDS-PAGE analysis, HPLC, Western Blotting and protein modifications e.g. biotinylation Track record of delivering results across a diverse project portfolio by leading and driving strategic and scientific initiatives Our organisation values are designed to guide all that we do. Bold: Act with ambition, courage and determination Credible: Act with rigour and professionalism Human : Act to have a positive impact on people Together: Act inclusively and collaboratively We're looking for people who can believe in and embody these organisation values and can use them to drive forward progress against our mission to beat cancer. If you're interested in applying and excited about working with us but are unsure if you have the right skills and experience, we'd still love to hear from you. What will I gain? We create a working environment that supports your wellbeing and provide a generous benefits package, a wide range of career and personal development opportunities and high-quality tools. Our policies and processes enable you to improve your work-life balance, take positive steps in your career and achieve your personal wellbeing goals. You can explore our benefits by visiting our careers web page. How do I apply? We operate an anonymised shortlisting process in our commitment to equality, diversity and inclusion. CVs are required for all applications; but we won't be able to view them until we invite you for an interview. Instead, we ask you to complete the work history section of the online application form for us to be able to assess you fairly and objectively. For more information on this career opportunity please visit our website or contact us. For more updates on our work and careers, follow us on: Linked In, Facebook, Instagram, X and YouTube.
Cedent
Basingstoke, Hampshire
Senior Scientist, Analytical Development (Chemistry) (Bedford, MA) We are looking to recruit a hands on highly talented Senior Scientist to manage the Analytical Development (AD) Chemistry team, providing onsite support and development for chemistry assays. This onsite Bedford, MA based role is an exciting opportunity to join an experienced organization whose mission is to enable our clients to deliver life changing therapies to patients. Responsibilities Lead and manage the Analytical Development Chemistry team responsible for installation of new equipment, assay development and the daily operation of HPLC, LC/MS, CE SDS, SEC and AUC development operations. Work in close collaboration with the AD Chemistry team to support client projects serving as the analytical methods expert to client teams. Lead and support the transfer, qualification, and validation of GMP analytical methods including but not limited to LC/MS, HPLC, Capillary Electrophoresis, (CE SDS), and AUC assays. Ensure AD Chemistry team members write protocols and generate reports related to QC method transfer, qualification, and validation activities. Provide training and supervision to junior scientists on assay development, instrumentation, and data interpretation. Support and monitor ongoing analytical method performance (e.g., system suitability trending, costing for new client projects) to drive continued improvement and optimization of client's analytical methods. Assist with data trending of assay controls and reference standards, as needed. Lead and support analytical method troubleshooting, as needed. Partner with internal and cross functional departments (e.g., QC and QA) to ensure on time delivery of client projects. Qualifications MS/PhD in Chemistry or related area. Over 10 years of related experience with LC/MS, HPLC, CE SDS and AUC. Proven people manager with the ability to shape teams. Strong expertise in analytical HPLC and LC/MS method development and basic troubleshooting. Independently motivated, detail oriented, and strong problem solving ability. Hands on experience in method development, qualification, validation and/or transfer. Knowledge of quality principles and GMP, ICH and GLP regulations. Experience creating/revising/reviewing operational SOPs, technical documents, protocols, and reports. Ability to work effectively in a fast paced environment. Excellent communication, technical, organizational, and interpersonal skills are essential. Ability to work effectively in a collaborative team environment where results are achieved through influence and the incorporation of multiple points of view.
Senior Scientist, Analytical Development (Chemistry) (Bedford, MA) We are looking to recruit a hands on highly talented Senior Scientist to manage the Analytical Development (AD) Chemistry team, providing onsite support and development for chemistry assays. This onsite Bedford, MA based role is an exciting opportunity to join an experienced organization whose mission is to enable our clients to deliver life changing therapies to patients. Responsibilities Lead and manage the Analytical Development Chemistry team responsible for installation of new equipment, assay development and the daily operation of HPLC, LC/MS, CE SDS, SEC and AUC development operations. Work in close collaboration with the AD Chemistry team to support client projects serving as the analytical methods expert to client teams. Lead and support the transfer, qualification, and validation of GMP analytical methods including but not limited to LC/MS, HPLC, Capillary Electrophoresis, (CE SDS), and AUC assays. Ensure AD Chemistry team members write protocols and generate reports related to QC method transfer, qualification, and validation activities. Provide training and supervision to junior scientists on assay development, instrumentation, and data interpretation. Support and monitor ongoing analytical method performance (e.g., system suitability trending, costing for new client projects) to drive continued improvement and optimization of client's analytical methods. Assist with data trending of assay controls and reference standards, as needed. Lead and support analytical method troubleshooting, as needed. Partner with internal and cross functional departments (e.g., QC and QA) to ensure on time delivery of client projects. Qualifications MS/PhD in Chemistry or related area. Over 10 years of related experience with LC/MS, HPLC, CE SDS and AUC. Proven people manager with the ability to shape teams. Strong expertise in analytical HPLC and LC/MS method development and basic troubleshooting. Independently motivated, detail oriented, and strong problem solving ability. Hands on experience in method development, qualification, validation and/or transfer. Knowledge of quality principles and GMP, ICH and GLP regulations. Experience creating/revising/reviewing operational SOPs, technical documents, protocols, and reports. Ability to work effectively in a fast paced environment. Excellent communication, technical, organizational, and interpersonal skills are essential. Ability to work effectively in a collaborative team environment where results are achieved through influence and the incorporation of multiple points of view.
