About Us Pure Healthcare are the UK s leading healthcare recruitment agency, committed to delivering service excellence. We have many years of framework healthcare recruitment experience. We have built up a wide network of contacts, clients and resources within our business to support clinicians throughout their professional career whilst also supporting healthcare organisations with their gaps in service to ensure patient care and quality. Our specialist consultants are dedicated to finding you the perfect role. The Role: Pure Healthcare Group are currently seeking a Biomedical Scientist to work in a toxicology laboratory with our clients in Manchester. Job Ref: PHG05159 Job Title: Biomedical Scientist Laboratory: Toxicology Hours: 37.5 hours a week Pay rates: £25 - £30/hr Location: Manchester To be considered for the role you must have the following: Valid Right to Work Documentation Mass Spectrometry experience Benefits include: Fast, automated compliance process Designated specialist consultant 24/7 support we re here whenever you need us! Lucrative career opportunities across the UK Enhanced pay rates CV advice Career advice Accommodation and travel assistance Smooth and reliable payroll options Know someone who would be a great fit? Refer a friend or colleague and earn a £250 referral bonus upon their successful placement! (T&Cs apply).
Feb 06, 2026
Contractor
About Us Pure Healthcare are the UK s leading healthcare recruitment agency, committed to delivering service excellence. We have many years of framework healthcare recruitment experience. We have built up a wide network of contacts, clients and resources within our business to support clinicians throughout their professional career whilst also supporting healthcare organisations with their gaps in service to ensure patient care and quality. Our specialist consultants are dedicated to finding you the perfect role. The Role: Pure Healthcare Group are currently seeking a Biomedical Scientist to work in a toxicology laboratory with our clients in Manchester. Job Ref: PHG05159 Job Title: Biomedical Scientist Laboratory: Toxicology Hours: 37.5 hours a week Pay rates: £25 - £30/hr Location: Manchester To be considered for the role you must have the following: Valid Right to Work Documentation Mass Spectrometry experience Benefits include: Fast, automated compliance process Designated specialist consultant 24/7 support we re here whenever you need us! Lucrative career opportunities across the UK Enhanced pay rates CV advice Career advice Accommodation and travel assistance Smooth and reliable payroll options Know someone who would be a great fit? Refer a friend or colleague and earn a £250 referral bonus upon their successful placement! (T&Cs apply).
We're working with a growing biopharma environment looking for a senior-level analytical leader to take ownership of analytical activities supporting biologic products as they move from development into routine manufacture. This is a hands-on technical role with real influence - shaping analytical approaches, supporting technology transfer, and ensuring methods remain robust, compliant, and fit for purpose across the product lifecycle. What you'll be doing: Setting and driving analytical approaches for biologic programmes, from development through to commercial supply Leading method development, validation, optimisation, and ongoing lifecycle improvements Supporting tech transfer and scale-up activities, working closely with manufacturing and MSAT teams Overseeing analytical data review, interpretation, and technical reporting Acting as a key analytical voice for regulatory activities, audits, and submissions Introducing new techniques, methods, and equipment to strengthen analytical capability Providing technical guidance and mentoring to more junior scientists within the team What they're looking for: Strong background in pharmaceutical analytical development within a CMC setting Solid experience working with biologics, including characterisation and method lifecycle management Proven ability to lead technical workstreams and influence cross-functional teams Comfortable working across quality, manufacturing, regulatory, and external partners Clear communicator who can balance technical depth with practical decision-making This would suit someone who enjoys being technically close to the work, while also shaping strategy and standards across analytical activities.
Feb 03, 2026
Full time
We're working with a growing biopharma environment looking for a senior-level analytical leader to take ownership of analytical activities supporting biologic products as they move from development into routine manufacture. This is a hands-on technical role with real influence - shaping analytical approaches, supporting technology transfer, and ensuring methods remain robust, compliant, and fit for purpose across the product lifecycle. What you'll be doing: Setting and driving analytical approaches for biologic programmes, from development through to commercial supply Leading method development, validation, optimisation, and ongoing lifecycle improvements Supporting tech transfer and scale-up activities, working closely with manufacturing and MSAT teams Overseeing analytical data review, interpretation, and technical reporting Acting as a key analytical voice for regulatory activities, audits, and submissions Introducing new techniques, methods, and equipment to strengthen analytical capability Providing technical guidance and mentoring to more junior scientists within the team What they're looking for: Strong background in pharmaceutical analytical development within a CMC setting Solid experience working with biologics, including characterisation and method lifecycle management Proven ability to lead technical workstreams and influence cross-functional teams Comfortable working across quality, manufacturing, regulatory, and external partners Clear communicator who can balance technical depth with practical decision-making This would suit someone who enjoys being technically close to the work, while also shaping strategy and standards across analytical activities.
A leading biotechnology company in Oxford is seeking a Senior Principal Scientist Biotransformation to drive biotransformation support for drug discovery. The candidate will leverage expertise in mass spectrometry and metabolite identification to contribute to critical projects. Responsibilities include designing metabolic studies, troubleshooting biotransformation issues, and mentoring junior scientists. A BSc is required and a PhD is desirable. This is an on-site role with a focus on innovation and data integrity.
Feb 02, 2026
Full time
A leading biotechnology company in Oxford is seeking a Senior Principal Scientist Biotransformation to drive biotransformation support for drug discovery. The candidate will leverage expertise in mass spectrometry and metabolite identification to contribute to critical projects. Responsibilities include designing metabolic studies, troubleshooting biotransformation issues, and mentoring junior scientists. A BSc is required and a PhD is desirable. This is an on-site role with a focus on innovation and data integrity.
Senior Principal Scientist Biotransformation page is loaded Senior Principal Scientist Biotransformationlocations: Oxford, United Kingdomtime type: Full timeposted on: Posted 2 Days Agotime left to apply: End Date: February 9, 2026 (21 days left to apply)job requisition id: REQ-27703 Job Description General Summary: Vertex is seeking a highly motivated and experienced Senior Principal Biotransformation Scientist to join our Oxford team. The successful candidate will play a leading role in the delivery of biotransformation and metabolite characterization support to our drug discovery and development projects. The successful candidate will have a deep analytical background in high resolution mass spectrometry and metabolite identification with an established track record for designing, executing and interpreting bespoke biotransformation studies. They will be responsible for the delivery of critical in vitro and in vivo biotransformation knowledge to aid medicinal chemistry design and influence key decisions impacting drug discovery and clinical development. Key Duties and Responsibilities: Provide mass spectrometry and metabolite identification expertise to the DMPK organization, keeping abreast of new scientific developments related to biotransformation science Proactively apply deep biotransformation scientific expertise to design and deliver metabolism studies in line with DMPK and project key deliverables Understand, interpret, and communicate biotransformation data to Project Representatives and key stakeholders to aid medicinal chemistry design and influence key decisions Be able to troubleshoot, problem-solve and define best practice for biotransformation studies Drive innovation by investigating and implementing new analytical technologies and procedures Contribute to the wider global biotransformation strategy to grow biotransformation science at Vertex Create internal and external networks to drive science within their discipline Author study reports Ensure high levels of data integrity and data accessibility Provide training and mentoring to more junior biotransformation colleagues Knowledge and Skills: Proven ability of metabolite characterisation and quantification using high resolution mass spectrometry and state-of-the-art metabolite acquisition and processing software Deep knowledge of biotransformations with extensive proven experience applying this to drug discovery and development programs Good understanding of in vitro and in vivo approaches used to understand biotransformation issues Ability to work in a matrix environment and problem solve with an extensive track record of generating high quality data and reports Excellent communication, interpersonal and team working skills Track record of developing more junior biotransformation scientists Education and Experience: BSc or equivalent in relevant field (PhD desirable) or equivalent relevant working experience. Flex Designation: On-Site Designated Flex Eligibility Status: In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Program and may be changed at any time. Company Information Vertex is a global biotechnology company that invests in scientific innovation.Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at
Feb 02, 2026
Full time
Senior Principal Scientist Biotransformation page is loaded Senior Principal Scientist Biotransformationlocations: Oxford, United Kingdomtime type: Full timeposted on: Posted 2 Days Agotime left to apply: End Date: February 9, 2026 (21 days left to apply)job requisition id: REQ-27703 Job Description General Summary: Vertex is seeking a highly motivated and experienced Senior Principal Biotransformation Scientist to join our Oxford team. The successful candidate will play a leading role in the delivery of biotransformation and metabolite characterization support to our drug discovery and development projects. The successful candidate will have a deep analytical background in high resolution mass spectrometry and metabolite identification with an established track record for designing, executing and interpreting bespoke biotransformation studies. They will be responsible for the delivery of critical in vitro and in vivo biotransformation knowledge to aid medicinal chemistry design and influence key decisions impacting drug discovery and clinical development. Key Duties and Responsibilities: Provide mass spectrometry and metabolite identification expertise to the DMPK organization, keeping abreast of new scientific developments related to biotransformation science Proactively apply deep biotransformation scientific expertise to design and deliver metabolism studies in line with DMPK and project key deliverables Understand, interpret, and communicate biotransformation data to Project Representatives and key stakeholders to aid medicinal chemistry design and influence key decisions Be able to troubleshoot, problem-solve and define best practice for biotransformation studies Drive innovation by investigating and implementing new analytical technologies and procedures Contribute to the wider global biotransformation strategy to grow biotransformation science at Vertex Create internal and external networks to drive science within their discipline Author study reports Ensure high levels of data integrity and data accessibility Provide training and mentoring to more junior biotransformation colleagues Knowledge and Skills: Proven ability of metabolite characterisation and quantification using high resolution mass spectrometry and state-of-the-art metabolite acquisition and processing software Deep knowledge of biotransformations with extensive proven experience applying this to drug discovery and development programs Good understanding of in vitro and in vivo approaches used to understand biotransformation issues Ability to work in a matrix environment and problem solve with an extensive track record of generating high quality data and reports Excellent communication, interpersonal and team working skills Track record of developing more junior biotransformation scientists Education and Experience: BSc or equivalent in relevant field (PhD desirable) or equivalent relevant working experience. Flex Designation: On-Site Designated Flex Eligibility Status: In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Program and may be changed at any time. Company Information Vertex is a global biotechnology company that invests in scientific innovation.Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at
Synexa Life Sciences (Pty) Ltd.
Macclesfield, Cheshire
A leading life sciences organization seeks a Principal Scientist I specializing in Mass Spectrometry to drive scientific growth within their team. This role involves developing bioanalytical assays, mentoring junior staff, and engaging in business development through proposal writing and client interactions. The ideal candidate will have a PhD or advanced degree with substantial industry experience and a strong background in regulated environments. Join a passionate team dedicated to scientific excellence in an innovative setting.
Feb 02, 2026
Full time
A leading life sciences organization seeks a Principal Scientist I specializing in Mass Spectrometry to drive scientific growth within their team. This role involves developing bioanalytical assays, mentoring junior staff, and engaging in business development through proposal writing and client interactions. The ideal candidate will have a PhD or advanced degree with substantial industry experience and a strong background in regulated environments. Join a passionate team dedicated to scientific excellence in an innovative setting.
Synexa Life Sciences (Pty) Ltd.
Macclesfield, Cheshire
Job Purpose The Principal Scientist I (Mass Spectrometry) aids in driving strategic scientific growth within our mass spectrometry group by leading high impact value creation initiatives, mentoring junior staff, and expanding in house capabilities. You will support business development through scientific proposal writing, client interactions, and by serving as a subject matter expert on advanced bioanalytical assays with predominantly LC MS endpoints. Your leadership will champion scientific excellence, reinforce GxP compliance, and elevate our CRO's reputation via publications, workshops, and cross functional collaborations. Main Areas of Responsibility Business Development & Scientific Strategy Collaborate with BD teams to develop scientific content for proposals, drive technical discussions with clients, and cultivate long term relationships. Identify emerging industry needs and overseeing Value Creation Projects (VCPs) and advancing in house capabilities to expand our assay portfolio. Assay SME & Method Innovation Lead feasibility studies and perform/oversee method development for the complex bioanalytical assays requested by our clients (including small molecules, large molecules, and new modalities at all stages of the development cycle). Lead transfer of the methods to study delivery group for validation and sample analysis, and monitoring study progress as the methods are employed. Serve as the SME for complex bioanalytical assays (scientific rationale, sample preparation, chromatography, mass spectrometry, hybrid applications, trouble shooting etc). Leadership & Mentoring Mentor and train junior and mid level scientists on advanced assay design, troubleshooting, data analysis, regulatory requirements and GxP documentation. Delegate responsibilities and review deliverables to ensure scientific rigor, data integrity, and on time delivery. Scientific Excellence & External Engagement Drive continuous improvement through internal audits, protocol enhancements, and corrective preventive action initiatives. Represent the company at scientific conferences, workshops, and in peer reviewed publications to showcase our capabilities and thought leadership. Qualifications & Experience PhD in Chemistry, Biochemistry, Biology or related discipline with 2 years' industry experience OR MSc/BSc in a relevant field with 7 years' hands on experience. Deep expertise in regulated bioanalytical environments (GLP/GCP) and familiarity with ICH bioanalytical guidelines. Demonstrated track record leading/performing development of bioanalytical LC MS assays for PK and/or PD applications in biological fluids and tissues using triple quadrupole instruments. Excellent leadership, project management, and cross functional collaboration skills. Proven experience in business facing roles: proposal writing, client presentations, and technical negotiations. Strong written and verbal communication skills in English. Preferred Skills & Experience Experience in the bioanalytical quantitation of large molecules and new modalities using LC MS. History of leading or co authoring peer reviewed publications or patents in bioanalysis. Performed role of Study Director/ Principal Investigator/ Responsible Scientist in the support of regulatory studies. Bioanalytical CRO experience. Experienced user of high resolution mass spectrometers. Experience of interactions with health authorities (FDA, EMA, MHRA).
Feb 02, 2026
Full time
Job Purpose The Principal Scientist I (Mass Spectrometry) aids in driving strategic scientific growth within our mass spectrometry group by leading high impact value creation initiatives, mentoring junior staff, and expanding in house capabilities. You will support business development through scientific proposal writing, client interactions, and by serving as a subject matter expert on advanced bioanalytical assays with predominantly LC MS endpoints. Your leadership will champion scientific excellence, reinforce GxP compliance, and elevate our CRO's reputation via publications, workshops, and cross functional collaborations. Main Areas of Responsibility Business Development & Scientific Strategy Collaborate with BD teams to develop scientific content for proposals, drive technical discussions with clients, and cultivate long term relationships. Identify emerging industry needs and overseeing Value Creation Projects (VCPs) and advancing in house capabilities to expand our assay portfolio. Assay SME & Method Innovation Lead feasibility studies and perform/oversee method development for the complex bioanalytical assays requested by our clients (including small molecules, large molecules, and new modalities at all stages of the development cycle). Lead transfer of the methods to study delivery group for validation and sample analysis, and monitoring study progress as the methods are employed. Serve as the SME for complex bioanalytical assays (scientific rationale, sample preparation, chromatography, mass spectrometry, hybrid applications, trouble shooting etc). Leadership & Mentoring Mentor and train junior and mid level scientists on advanced assay design, troubleshooting, data analysis, regulatory requirements and GxP documentation. Delegate responsibilities and review deliverables to ensure scientific rigor, data integrity, and on time delivery. Scientific Excellence & External Engagement Drive continuous improvement through internal audits, protocol enhancements, and corrective preventive action initiatives. Represent the company at scientific conferences, workshops, and in peer reviewed publications to showcase our capabilities and thought leadership. Qualifications & Experience PhD in Chemistry, Biochemistry, Biology or related discipline with 2 years' industry experience OR MSc/BSc in a relevant field with 7 years' hands on experience. Deep expertise in regulated bioanalytical environments (GLP/GCP) and familiarity with ICH bioanalytical guidelines. Demonstrated track record leading/performing development of bioanalytical LC MS assays for PK and/or PD applications in biological fluids and tissues using triple quadrupole instruments. Excellent leadership, project management, and cross functional collaboration skills. Proven experience in business facing roles: proposal writing, client presentations, and technical negotiations. Strong written and verbal communication skills in English. Preferred Skills & Experience Experience in the bioanalytical quantitation of large molecules and new modalities using LC MS. History of leading or co authoring peer reviewed publications or patents in bioanalysis. Performed role of Study Director/ Principal Investigator/ Responsible Scientist in the support of regulatory studies. Bioanalytical CRO experience. Experienced user of high resolution mass spectrometers. Experience of interactions with health authorities (FDA, EMA, MHRA).
